Assay Detail
Binding
CHEMBL865646
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Inhibition of HCV NS5B RNA dependent RNA polymerase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.88 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204350 | — | — | 1 | 8.77 |
| CHEMBL205341 | — | — | 1 | 7.75 |
| CHEMBL204628 | — | — | 1 | 7.66 |
| CHEMBL381613 | — | — | 1 | 7.23 |
| CHEMBL205579 | — | — | 1 | 7.06 |
| CHEMBL205648 | — | — | 1 | 6.83 |
| CHEMBL176058 | — | — | 1 | 6.70 |
| CHEMBL203783 | — | — | 1 | 6.31 |
| CHEMBL383501 | — | — | 1 | 6.28 |
| CHEMBL204724 | — | — | 1 | 5.61 |
| CHEMBL208325 | — | — | 1 | 5.45 |
| CHEMBL383514 | — | — | 1 | - |
| CHEMBL382191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204350 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL205341 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL204628 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL381613 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL205579 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL205648 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL176058 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL203783 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL383501 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL204724 | — | IC50 | = | 2466.0 | nM | 5.61 |
| CHEMBL208325 | — | IC50 | = | 3567.0 | nM | 5.45 |
| CHEMBL383514 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL382191 | — | IC50 | > | 748.0 | nM | - |