Assay Detail
Binding
CHEMBL865715
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Inhibition of trypsin
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.06 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208140 | — | — | 1 | 8.80 |
| CHEMBL206205 | — | — | 1 | 8.72 |
| CHEMBL377681 | — | — | 1 | 8.32 |
| CHEMBL266349 | MELAGATRAN | 4.0 | 1 | 7.92 |
| CHEMBL381709 | — | — | 1 | 7.68 |
| CHEMBL207981 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208140 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL206205 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL377681 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL266349 | MELAGATRAN | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL381709 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL207981 | — | IC50 | = | 117.0 | nM | 6.93 |