Assay Detail
Binding
CHEMBL865716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tPA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.65 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208140 | — | — | 1 | 7.16 |
| CHEMBL206205 | — | — | 1 | 6.90 |
| CHEMBL381709 | — | — | 1 | 6.76 |
| CHEMBL377681 | — | — | 1 | 6.27 |
| CHEMBL207981 | — | — | 1 | 6.16 |
| CHEMBL266349 | MELAGATRAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208140 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL206205 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL381709 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL377681 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL207981 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL266349 | MELAGATRAN | IC50 | - | — | - |