Assay Detail
Binding
CHEMBL865717
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Inhibition of plasmin
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.89 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381709 | — | — | 1 | 6.70 |
| CHEMBL208140 | — | — | 1 | 5.91 |
| CHEMBL206205 | — | — | 1 | 5.83 |
| CHEMBL266349 | MELAGATRAN | 4.0 | 1 | 5.51 |
| CHEMBL377681 | — | — | 1 | 5.49 |
| CHEMBL207981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381709 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL208140 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL206205 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL266349 | MELAGATRAN | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL377681 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL207981 | — | IC50 | > | 20000.0 | nM | - |