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Assay Detail

CHEMBL865719

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Aorta
Confidence 9 — Direct single protein target
Curated By Expert

Target

Alpha-1D adrenergic receptor (CHEMBL326)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties.
Boschi D, Tron GC, Lazzarato L, Chegaev K, Cena C, Di Stilo A, Giorgis M, Bertinaria M, Fruttero R, Gasco A.
J Med Chem (2006) 49 : 2886 -2897
PubMed 16686532 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 6.22 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL189804 1 7.92
CHEMBL363325 1 7.92
CHEMBL208390 1 7.66
CHEMBL360593 1 7.36
CHEMBL187824 1 6.96
CHEMBL207967 1 6.89
CHEMBL206527 1 6.62
CHEMBL207448 1 6.39
CHEMBL381054 1 6.19
CHEMBL188760 1 6.00
CHEMBL188200 1 5.92
CHEMBL380475 1 5.82
CHEMBL207437 1 5.51
CHEMBL381519 1 5.48
CHEMBL207183 1 5.37
CHEMBL206100 1 5.20
CHEMBL187933 1 4.40
CHEMBL188554 1 4.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL189804 EC50 = 12.0 nM 7.92
CHEMBL363325 EC50 = 12.0 nM 7.92
CHEMBL208390 EC50 = 22.0 nM 7.66
CHEMBL360593 EC50 = 44.0 nM 7.36
CHEMBL187824 EC50 = 110.0 nM 6.96
CHEMBL207967 EC50 = 130.0 nM 6.89
CHEMBL206527 EC50 = 240.0 nM 6.62
CHEMBL207448 EC50 = 410.0 nM 6.39
CHEMBL381054 EC50 = 640.0 nM 6.19
CHEMBL188760 EC50 = 1000.0 nM 6.00
CHEMBL188200 EC50 = 1200.0 nM 5.92
CHEMBL380475 EC50 = 1500.0 nM 5.82
CHEMBL207437 EC50 = 3100.0 nM 5.51
CHEMBL381519 EC50 = 3300.0 nM 5.48
CHEMBL207183 EC50 = 4300.0 nM 5.37
CHEMBL206100 EC50 = 6300.0 nM 5.20
CHEMBL187933 EC50 = 40000.0 nM 4.40
CHEMBL188554 EC50 = 41000.0 nM 4.39