Assay Detail
Binding
CHEMBL865933
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Inhibition of COX1 by canine whole blood assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin G/H synthase 1 (CHEMBL4133) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.67 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426117 | — | — | 1 | 7.00 |
| CHEMBL202856 | — | — | 1 | 7.00 |
| CHEMBL381971 | — | — | 1 | 6.70 |
| CHEMBL381158 | — | — | 1 | 6.70 |
| CHEMBL381716 | — | — | 1 | 6.40 |
| CHEMBL204178 | — | — | 1 | 6.22 |
| CHEMBL204506 | — | — | 1 | 6.05 |
| CHEMBL204707 | — | — | 1 | 5.82 |
| CHEMBL203697 | — | — | 1 | 5.70 |
| CHEMBL380329 | — | — | 1 | 5.50 |
| CHEMBL427380 | — | — | 1 | 5.48 |
| CHEMBL264572 | — | — | 1 | 5.46 |
| CHEMBL205163 | — | — | 1 | 5.15 |
| CHEMBL381363 | — | — | 1 | 5.12 |
| CHEMBL381304 | — | — | 1 | 5.10 |
| CHEMBL383207 | — | — | 1 | 5.00 |
| CHEMBL204641 | — | — | 1 | 4.97 |
| CHEMBL413045 | — | — | 1 | 4.93 |
| CHEMBL204703 | — | — | 1 | 4.60 |
| CHEMBL377499 | — | — | 1 | 4.53 |
| CHEMBL200812 | — | — | 1 | - |
| CHEMBL204029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426117 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL202856 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL381971 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL381158 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL381716 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL204178 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL204506 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL204707 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL203697 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL380329 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL427380 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL264572 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL205163 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL381363 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL381304 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL383207 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL204641 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL413045 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL204703 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL377499 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL200812 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL204029 | — | IC50 | > | 50000.0 | nM | - |