Assay Detail
Binding
CHEMBL866012
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Inhibition of JNK1
18
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.90 | 8.40 |
| Ki | 2 | 7.41 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377383 | — | — | 2 | 8.42 |
| CHEMBL211584 | — | — | 1 | 8.40 |
| CHEMBL377408 | — | — | 1 | 7.92 |
| CHEMBL424872 | — | — | 1 | 7.72 |
| CHEMBL209534 | — | — | 1 | 7.58 |
| CHEMBL210618 | — | — | 1 | 7.35 |
| CHEMBL214212 | — | — | 1 | 7.15 |
| CHEMBL439323 | — | — | 1 | 7.12 |
| CHEMBL209740 | — | — | 1 | 6.64 |
| CHEMBL211195 | — | — | 1 | 6.57 |
| CHEMBL377991 | — | — | 1 | 6.41 |
| CHEMBL211605 | — | — | 2 | 6.40 |
| CHEMBL208637 | — | — | 1 | 6.08 |
| CHEMBL209397 | — | — | 1 | 5.82 |
| CHEMBL378955 | — | — | 1 | 5.19 |
| CHEMBL209049 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377383 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL211584 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL377408 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL424872 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL377383 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL209534 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL210618 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL214212 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL439323 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL209740 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL211195 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL377991 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL211605 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL208637 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL211605 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL209397 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL378955 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL209049 | — | IC50 | > | 10000.0 | nM | - |