Assay Detail
Binding
CHEMBL866015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]echistatin binding to integrin alphaVbeta3 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.67 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378530 | — | — | 1 | 10.52 |
| CHEMBL212414 | — | — | 1 | 7.75 |
| CHEMBL212315 | — | — | 1 | 7.62 |
| CHEMBL426146 | — | — | 1 | 7.28 |
| CHEMBL211163 | — | — | 1 | 6.62 |
| CHEMBL377411 | — | — | 1 | 6.22 |
| CHEMBL211589 | — | — | 1 | - |
| CHEMBL214002 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378530 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL212414 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL212315 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL426146 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL211163 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL377411 | — | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL211589 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL214002 | — | IC50 | > | 1000.0 | nM | - |