Assay Detail
Functional
CHEMBL866019
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Cytotoxicity against human MDA-MB-435 cell line by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.47 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211163 | — | — | 1 | 6.47 |
| CHEMBL211589 | — | — | 1 | 5.55 |
| CHEMBL214002 | — | — | 1 | 5.10 |
| CHEMBL209327 | — | — | 1 | 4.75 |
| CHEMBL378530 | — | — | 1 | - |
| CHEMBL212315 | — | — | 1 | - |
| CHEMBL377411 | — | — | 1 | - |
| CHEMBL212414 | — | — | 1 | - |
| CHEMBL209807 | — | — | 1 | - |
| CHEMBL426146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211163 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL211589 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL214002 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL209327 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL378530 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL212315 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL377411 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL212414 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL209807 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL426146 | — | IC50 | > | 20000.0 | nM | - |