Assay Detail
Functional
CHEMBL866024
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Inhibition of cJun phosphorylation in HepG2 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.10 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377408 | — | — | 1 | 6.96 |
| CHEMBL439323 | — | — | 1 | 6.39 |
| CHEMBL377383 | — | — | 1 | 6.32 |
| CHEMBL424872 | — | — | 1 | 6.28 |
| CHEMBL214212 | — | — | 1 | 6.19 |
| CHEMBL211195 | — | — | 1 | 5.96 |
| CHEMBL209534 | — | — | 1 | 5.92 |
| CHEMBL209740 | — | — | 1 | 5.60 |
| CHEMBL377991 | — | — | 1 | 5.24 |
| CHEMBL209397 | — | — | 1 | - |
| CHEMBL378955 | — | — | 1 | - |
| CHEMBL211584 | — | — | 1 | - |
| CHEMBL211605 | — | — | 1 | - |
| CHEMBL209049 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377408 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL439323 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL377383 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL424872 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL214212 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL211195 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL209534 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL209740 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL377991 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL209397 | — | IC50 | - | — | - | |
| CHEMBL378955 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL211584 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL211605 | — | IC50 | - | — | - | |
| CHEMBL209049 | — | IC50 | - | — | - |