Assay Detail
Binding
CHEMBL866101
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Inhibition of human cathepsin B
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.68 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184514 | — | — | 1 | 5.42 |
| CHEMBL211737 | — | — | 1 | 4.92 |
| CHEMBL212907 | — | — | 1 | 4.75 |
| CHEMBL213930 | — | — | 1 | 4.66 |
| CHEMBL212879 | — | — | 1 | 4.43 |
| CHEMBL213194 | — | — | 1 | 4.29 |
| CHEMBL213244 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184514 | — | Ki | = | 3843.0 | nM | 5.42 |
| CHEMBL211737 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL212907 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL213930 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL212879 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL213194 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL213244 | — | Ki | = | 51000.0 | nM | 4.29 |