Assay Detail
Functional
CHEMBL866103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on degradation of bovine bone by rabbit osteoclast
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Osteoclast |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.19 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211737 | — | — | 1 | 7.92 |
| CHEMBL212879 | — | — | 1 | 7.55 |
| CHEMBL213194 | — | — | 1 | 7.37 |
| CHEMBL213930 | — | — | 1 | 7.23 |
| CHEMBL184514 | — | — | 1 | 7.02 |
| CHEMBL213244 | — | — | 1 | 6.76 |
| CHEMBL212907 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211737 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL212879 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL213194 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL213930 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL184514 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL213244 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL212907 | — | IC50 | = | 349.0 | nM | 6.46 |