Assay Detail
Functional
CHEMBL866173
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Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.80 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | 7.89 |
| CHEMBL1161882 | — | — | 1 | 7.82 |
| CHEMBL1161875 | — | — | 1 | 7.22 |
| CHEMBL384992 | — | — | 1 | 7.10 |
| CHEMBL212090 | — | — | 1 | 6.64 |
| CHEMBL1161880 | — | — | 1 | 6.55 |
| CHEMBL1161881 | — | — | 1 | 6.25 |
| CHEMBL1161884 | — | — | 1 | 6.10 |
| CHEMBL1161876 | — | — | 1 | 5.96 |
| CHEMBL609433 | — | — | 1 | 5.82 |
| CHEMBL1161885 | — | — | 1 | 5.77 |
| CHEMBL9519 | — | — | 1 | 5.76 |
| CHEMBL378445 | — | — | 1 | 5.64 |
| CHEMBL1161878 | — | — | 1 | 5.64 |
| CHEMBL612021 | — | — | 1 | 5.60 |
| CHEMBL215447 | — | — | 1 | 5.48 |
| CHEMBL1161887 | — | — | 1 | 5.46 |
| CHEMBL215911 | — | — | 1 | 5.41 |
| CHEMBL1161879 | — | — | 1 | 5.31 |
| CHEMBL1161886 | — | — | 1 | 5.26 |
| CHEMBL1161877 | — | — | 1 | 5.06 |
| CHEMBL1161874 | — | — | 1 | 4.75 |
| CHEMBL384759 | — | — | 1 | 4.35 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 4.19 |
| CHEMBL425252 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1161882 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1161875 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL384992 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL212090 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1161880 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1161881 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1161884 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1161876 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL609433 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1161885 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL9519 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL378445 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1161878 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL612021 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL215447 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1161887 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL215911 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1161879 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1161886 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1161877 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1161874 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL384759 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | EC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL425252 | — | EC50 | = | 88000.0 | nM | 4.06 |