Assay Detail
Functional
CHEMBL866255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of potassium-evoked [3H]norepinephrine release from rat neocortex
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Neocortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-dependent calcium channel subunit alpha-2/delta-1 (CHEMBL3420) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Carboxylate bioisosteres of gabapentin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.15 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378552 | — | — | 1 | 5.24 |
| CHEMBL940 | GABAPENTIN | 4.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378552 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL940 | GABAPENTIN | IC50 | = | 8900.0 | nM | 5.05 |