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Assay Detail

CHEMBL866259

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Binding
Inhibition of IMPDH2
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Low molecular weight indole fragments as IMPDH inhibitors.
Beevers RE, Buckley GM, Davies N, Fraser JL, Galvin FC, Hannah DR, Haughan AF, Jenkins K, Mack SR, Pitt WR, Ratcliffe AJ, Richard MD, Sabin V, Sharpe A, Williams SC.
Bioorg Med Chem Lett (2006) 16 : 2535 -2538
PubMed 16483769 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.53 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL207501 1 6.46
CHEMBL206257 1 6.39
CHEMBL207502 1 6.38
CHEMBL207262 1 6.28
CHEMBL207612 1 6.20
CHEMBL380071 1 5.94
CHEMBL206475 1 5.63
CHEMBL381132 1 5.23
CHEMBL207375 1 5.21
CHEMBL210779 1 5.17
CHEMBL205035 1 5.12
CHEMBL45870 1 5.09
CHEMBL46724 1 4.68
CHEMBL147741 3-FORMYLINDOLE 1 4.64
CHEMBL381184 1 4.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL207501 IC50 = 343.0 nM 6.46
CHEMBL206257 IC50 = 408.0 nM 6.39
CHEMBL207502 IC50 = 419.0 nM 6.38
CHEMBL207262 IC50 = 524.0 nM 6.28
CHEMBL207612 IC50 = 637.0 nM 6.20
CHEMBL380071 IC50 = 1150.0 nM 5.94
CHEMBL206475 IC50 = 2320.0 nM 5.63
CHEMBL381132 IC50 = 5840.0 nM 5.23
CHEMBL207375 IC50 = 6210.0 nM 5.21
CHEMBL210779 IC50 = 6840.0 nM 5.17
CHEMBL205035 IC50 = 7660.0 nM 5.12
CHEMBL45870 IC50 = 8200.0 nM 5.09
CHEMBL46724 IC50 = 20900.0 nM 4.68
CHEMBL147741 3-FORMYLINDOLE IC50 = 22700.0 nM 4.64
CHEMBL381184 IC50 = 27900.0 nM 4.55