Assay Detail
Binding
CHEMBL866272
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Inhibition of IMPDH2
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.61 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380639 | — | — | 1 | 7.12 |
| CHEMBL206886 | — | — | 1 | 7.08 |
| CHEMBL208219 | — | — | 1 | 6.89 |
| CHEMBL379524 | — | — | 1 | 6.65 |
| CHEMBL380132 | — | — | 1 | 6.44 |
| CHEMBL207621 | — | — | 1 | 6.34 |
| CHEMBL208261 | — | — | 1 | 6.23 |
| CHEMBL333482 | — | — | 1 | 6.14 |
| CHEMBL205218 | — | — | 1 | 5.96 |
| CHEMBL380071 | — | — | 1 | 5.94 |
| CHEMBL426498 | — | — | 1 | 5.93 |
| CHEMBL205051 | — | — | 1 | 5.87 |
| CHEMBL378169 | — | — | 1 | 5.39 |
| CHEMBL377529 | — | — | 1 | 5.21 |
| CHEMBL205035 | — | — | 1 | 5.12 |
| CHEMBL205236 | — | — | 1 | 5.12 |
| CHEMBL379401 | — | — | 1 | 5.11 |
| CHEMBL205328 | — | — | 1 | 4.81 |
| CHEMBL208524 | — | — | 1 | 4.77 |
| CHEMBL207730 | — | — | 1 | 4.71 |
| CHEMBL378273 | — | — | 1 | 4.68 |
| CHEMBL46724 | — | — | 1 | 4.68 |
| CHEMBL206945 | — | — | 1 | 4.23 |
| CHEMBL377680 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380639 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL206886 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL208219 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL379524 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL380132 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL207621 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL208261 | — | IC50 | = | 586.0 | nM | 6.23 |
| CHEMBL333482 | — | IC50 | = | 722.0 | nM | 6.14 |
| CHEMBL205218 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL380071 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL426498 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL205051 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL378169 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL377529 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL205035 | — | IC50 | = | 7660.0 | nM | 5.12 |
| CHEMBL205236 | — | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL379401 | — | IC50 | = | 7850.0 | nM | 5.11 |
| CHEMBL205328 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL208524 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL207730 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL378273 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL46724 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL206945 | — | IC50 | = | 58400.0 | nM | 4.23 |
| CHEMBL377680 | — | IC50 | = | 71800.0 | nM | 4.14 |