Assay Detail
Binding
CHEMBL866276
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Inhibition of PI3 kinase p110alpha/p85-alpha complex
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.95 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382875 | — | — | 1 | 9.15 |
| CHEMBL428496 | WORTMANNIN | — | 1 | 8.92 |
| CHEMBL383037 | — | — | 1 | 8.72 |
| CHEMBL205591 | — | — | 1 | 8.02 |
| CHEMBL383415 | — | — | 1 | 8.00 |
| CHEMBL381040 | — | — | 1 | 6.65 |
| CHEMBL208279 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382875 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL428496 | WORTMANNIN | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL383037 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL205591 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL383415 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL381040 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL208279 | — | IC50 | = | 695.0 | nM | 6.16 |