Assay Detail
Functional
CHEMBL866365
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Antiproliferative activity against human A549 cell line
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.55 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.96 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.68 |
| CHEMBL209414 | — | — | 1 | 8.28 |
| CHEMBL182739 | — | — | 1 | 8.25 |
| CHEMBL210696 | — | — | 1 | 8.05 |
| CHEMBL379924 | — | — | 1 | 7.81 |
| CHEMBL210202 | — | — | 1 | 7.72 |
| CHEMBL378694 | — | — | 1 | 7.72 |
| CHEMBL211010 | — | — | 1 | 7.60 |
| CHEMBL377262 | — | — | 1 | 7.50 |
| CHEMBL207565 | — | — | 1 | 7.49 |
| CHEMBL210758 | — | — | 1 | 7.35 |
| CHEMBL321473 | — | — | 1 | 7.33 |
| CHEMBL379854 | — | — | 1 | 7.04 |
| CHEMBL209234 | — | — | 1 | 7.03 |
| CHEMBL377962 | — | — | 1 | 6.97 |
| CHEMBL210473 | — | — | 1 | 6.93 |
| CHEMBL378138 | — | — | 1 | 6.86 |
| CHEMBL377060 | — | — | 1 | 6.78 |
| CHEMBL209349 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL209414 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL182739 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL210696 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL379924 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL210202 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL378694 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL211010 | — | IC50 | = | 25.1 | nM | 7.60 |
| CHEMBL377262 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL207565 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL210758 | — | IC50 | = | 44.9 | nM | 7.35 |
| CHEMBL321473 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL379854 | — | IC50 | = | 90.2 | nM | 7.04 |
| CHEMBL209234 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL377962 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL210473 | — | IC50 | = | 118.3 | nM | 6.93 |
| CHEMBL378138 | — | IC50 | = | 136.7 | nM | 6.86 |
| CHEMBL377060 | — | IC50 | = | 166.3 | nM | 6.78 |
| CHEMBL209349 | — | IC50 | = | 226.0 | nM | 6.65 |