Assay Detail
Functional
CHEMBL866368
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant PPARalpha by transactivation of TK-MH100x4-LUC reporter gene in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.25 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210372 | — | — | 1 | 5.46 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | 5.04 |
| CHEMBL208819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210372 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL208819 | — | EC50 | - | — | - |