Assay Detail
Functional
CHEMBL866388
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Binding affinity at human GABAA alpha-4-beta-3-delta expressed in Xenopus oocytes by voltage-clamp electrophysiology
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.05 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202028 | — | — | 1 | 9.46 |
| CHEMBL377925 | — | — | 1 | 8.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202028 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL377925 | — | Ki | = | 2.3 | nM | 8.64 |