Assay Detail
Functional
CHEMBL866438
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Cytotoxicity against human mammary tumor cell line MCF7-S
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7S |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.46 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204644 | — | — | 1 | 9.89 |
| CHEMBL380432 | — | — | 1 | 9.85 |
| CHEMBL126678 | — | — | 1 | 9.74 |
| CHEMBL126916 | — | — | 1 | 9.70 |
| CHEMBL420349 | — | — | 1 | 9.46 |
| CHEMBL203874 | — | — | 1 | 9.29 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.77 |
| CHEMBL267441 | — | — | 1 | - |
| CHEMBL373801 | — | — | 1 | - |
| CHEMBL219521 | — | — | 1 | - |
| CHEMBL374359 | — | — | 1 | - |
| CHEMBL413474 | — | — | 1 | - |
| CHEMBL438238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204644 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL380432 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL126678 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL126916 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL420349 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL203874 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL267441 | — | IC50 | - | — | - | |
| CHEMBL373801 | — | IC50 | - | — | - | |
| CHEMBL219521 | — | IC50 | - | — | - | |
| CHEMBL374359 | — | IC50 | - | — | - | |
| CHEMBL413474 | — | IC50 | - | — | - | |
| CHEMBL438238 | — | IC50 | - | — | - |