Assay Detail
Binding
CHEMBL866442
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Inhibition of Integrin alphav-beta3 receptor by SPRA assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.59 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434191 | — | — | 1 | 9.59 |
| CHEMBL369981 | — | — | 1 | 9.40 |
| CHEMBL202295 | — | — | 1 | 9.30 |
| CHEMBL372290 | — | — | 1 | 9.19 |
| CHEMBL202081 | — | — | 1 | 9.11 |
| CHEMBL372749 | — | — | 1 | 9.00 |
| CHEMBL383366 | — | — | 1 | 8.96 |
| CHEMBL370776 | — | — | 1 | 8.92 |
| CHEMBL382743 | — | — | 1 | 8.89 |
| CHEMBL202564 | — | — | 1 | 8.85 |
| CHEMBL381663 | — | — | 1 | 8.80 |
| CHEMBL379444 | — | — | 1 | 8.77 |
| CHEMBL203690 | — | — | 1 | 8.76 |
| CHEMBL204797 | — | — | 1 | 8.74 |
| CHEMBL202342 | — | — | 1 | 8.70 |
| CHEMBL202531 | — | — | 1 | 8.68 |
| CHEMBL202397 | — | — | 1 | 8.68 |
| CHEMBL201568 | — | — | 1 | 8.62 |
| CHEMBL202697 | — | — | 1 | 8.44 |
| CHEMBL204259 | — | — | 1 | 8.06 |
| CHEMBL203799 | — | — | 1 | 8.02 |
| CHEMBL204693 | — | — | 1 | 7.92 |
| CHEMBL202527 | — | — | 1 | 7.70 |
| CHEMBL381389 | — | — | 1 | 6.94 |
| CHEMBL371973 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434191 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL369981 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL202295 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL372290 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL202081 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL372749 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL383366 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL370776 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL382743 | — | IC50 | = | 1.28 | nM | 8.89 |
| CHEMBL202564 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL381663 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL379444 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL203690 | — | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL204797 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL202342 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL202531 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL202397 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL201568 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL202697 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL204259 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL203799 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL204693 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL202527 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL381389 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL371973 | — | IC50 | = | 160.0 | nM | 6.80 |