Assay Detail
Binding
CHEMBL866445
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Inhibition of Integrin alphav-beta5 receptor expressed in HEK293 cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.46 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202564 | — | — | 1 | 8.92 |
| CHEMBL369981 | — | — | 1 | 8.77 |
| CHEMBL434191 | — | — | 1 | 8.54 |
| CHEMBL381663 | — | — | 1 | 8.48 |
| CHEMBL203690 | — | — | 1 | 8.43 |
| CHEMBL204259 | — | — | 1 | 8.40 |
| CHEMBL202081 | — | — | 1 | 8.34 |
| CHEMBL202531 | — | — | 1 | 7.80 |
| CHEMBL202295 | — | — | 1 | - |
| CHEMBL202397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202564 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL369981 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL434191 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL381663 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL203690 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL204259 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL202081 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL202531 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL202295 | — | IC50 | - | — | - | |
| CHEMBL202397 | — | IC50 | - | — | - |