Assay Detail
Binding
CHEMBL866517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 protease
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Microwave-accelerated synthesis of P1'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.97 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380970 | — | — | 1 | 8.68 |
| CHEMBL197500 | — | — | 1 | 8.62 |
| CHEMBL381588 | — | — | 1 | 8.46 |
| CHEMBL382473 | — | — | 1 | 8.42 |
| CHEMBL206467 | — | — | 1 | 8.30 |
| CHEMBL381326 | — | — | 1 | 8.26 |
| CHEMBL380522 | — | — | 1 | 8.11 |
| CHEMBL436952 | — | — | 1 | 8.05 |
| CHEMBL206509 | — | — | 1 | 7.96 |
| CHEMBL205176 | — | — | 1 | 7.96 |
| CHEMBL381169 | — | — | 1 | 7.92 |
| CHEMBL381770 | — | — | 1 | 7.92 |
| CHEMBL205359 | — | — | 1 | 7.85 |
| CHEMBL381168 | — | — | 1 | 7.82 |
| CHEMBL437507 | — | — | 1 | 7.82 |
| CHEMBL1203922 | — | — | 1 | 7.75 |
| CHEMBL204055 | — | — | 1 | 7.75 |
| CHEMBL202963 | — | — | 1 | 7.70 |
| CHEMBL382131 | — | — | 1 | 7.66 |
| CHEMBL383290 | — | — | 1 | 7.64 |
| CHEMBL410469 | — | — | 1 | 7.64 |
| CHEMBL382872 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380970 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL197500 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL381588 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL382473 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL206467 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL381326 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL380522 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL436952 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL206509 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL205176 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL381169 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL381770 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL205359 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL381168 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL437507 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1203922 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL204055 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL202963 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL382131 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL383290 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL410469 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL382872 | — | Ki | = | 93.0 | nM | 7.03 |