Assay Detail
Binding
CHEMBL866542
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Inhibition of human TR-beta-1 by radioligand binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.15 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203777 | — | — | 1 | 10.22 |
| CHEMBL557 | DETROTHYRONINE | 2.0 | 1 | 9.59 |
| CHEMBL425939 | — | — | 1 | 9.55 |
| CHEMBL203828 | — | — | 1 | 8.07 |
| CHEMBL203555 | — | — | 1 | 7.82 |
| CHEMBL378593 | — | — | 1 | 7.29 |
| CHEMBL251439 | — | — | 1 | 6.62 |
| CHEMBL250880 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203777 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL557 | DETROTHYRONINE | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL425939 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL203828 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL203555 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL378593 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL251439 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL250880 | — | IC50 | = | 870.0 | nM | 6.06 |