Assay Detail
Binding
CHEMBL866556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to MC1 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.84 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380120 | — | — | 1 | 8.05 |
| CHEMBL206033 | — | — | 1 | 7.52 |
| CHEMBL380437 | — | — | 1 | 7.15 |
| CHEMBL381357 | — | — | 1 | 5.64 |
| CHEMBL383256 | — | — | 1 | 5.40 |
| CHEMBL202699 | — | — | 1 | 5.34 |
| CHEMBL444883 | — | — | 1 | 5.07 |
| CHEMBL206018 | — | — | 1 | 4.91 |
| CHEMBL437132 | — | — | 1 | 4.65 |
| CHEMBL203252 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380120 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL206033 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL380437 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL381357 | — | Ki | = | 2276.0 | nM | 5.64 |
| CHEMBL383256 | — | Ki | = | 3992.0 | nM | 5.40 |
| CHEMBL202699 | — | Ki | = | 4520.0 | nM | 5.34 |
| CHEMBL444883 | — | Ki | = | 8562.0 | nM | 5.07 |
| CHEMBL206018 | — | Ki | = | 12288.0 | nM | 4.91 |
| CHEMBL437132 | — | Ki | = | 22267.0 | nM | 4.65 |
| CHEMBL203252 | — | Ki | = | 23400.0 | nM | 4.63 |