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Assay Detail

CHEMBL866585

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Bacillus anthracis LF by FRET assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 9 — Direct single protein target
Curated By Expert

Target

Lethal factor (CHEMBL4372)
Type SINGLE PROTEIN
Organism Bacillus anthracis

Publication

Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors.
Jiao GS, Cregar L, Goldman ME, Millis SZ, Tang C.
Bioorg Med Chem Lett (2006) 16 : 1527 -1531
PubMed 16386899 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 5.37 7.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL205548 1 7.19
CHEMBL380489 1 6.30
CHEMBL382908 1 6.22
CHEMBL206437 1 5.39
CHEMBL378362 1 5.18
CHEMBL203163 1 4.97
CHEMBL206411 1 4.83
CHEMBL203460 1 4.61
CHEMBL206323 1 4.51
CHEMBL205203 1 4.50
CHEMBL203164 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL205548 Ki = 65.0 nM 7.19
CHEMBL380489 Ki = 500.0 nM 6.30
CHEMBL382908 Ki = 600.0 nM 6.22
CHEMBL206437 Ki = 4100.0 nM 5.39
CHEMBL378362 Ki = 6600.0 nM 5.18
CHEMBL203163 Ki = 10700.0 nM 4.97
CHEMBL206411 Ki = 14900.0 nM 4.83
CHEMBL203460 Ki = 24800.0 nM 4.61
CHEMBL206323 Ki = 30600.0 nM 4.51
CHEMBL205203 Ki = 31400.0 nM 4.50
CHEMBL203164 Ki = 153700.0 nM -