Assay Detail
Binding
CHEMBL866610
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Inhibition of GSK3
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.47 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205795 | — | — | 1 | 8.30 |
| CHEMBL206010 | GW814408X | — | 1 | 8.30 |
| CHEMBL306865 | GW784752X | — | 1 | 8.20 |
| CHEMBL204886 | — | — | 1 | 7.50 |
| CHEMBL383525 | — | — | 1 | 6.30 |
| CHEMBL204934 | GW813360X | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205795 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL206010 | GW814408X | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL306865 | GW784752X | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL204886 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL383525 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL204934 | GW813360X | IC50 | = | 630.96 | nM | 6.20 |