Assay Detail
Binding
CHEMBL866615
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Inhibition of tubulin polymerization in bovine brain by tubulin assembly assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.82 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378632 | — | — | 1 | 6.01 |
| CHEMBL380060 | — | — | 1 | 5.96 |
| CHEMBL212515 | — | — | 1 | 5.96 |
| CHEMBL209011 | — | — | 1 | 5.77 |
| CHEMBL210239 | — | — | 1 | 5.77 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 5.77 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.77 |
| CHEMBL379867 | — | — | 1 | 5.72 |
| CHEMBL212734 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378632 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL380060 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL212515 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL209011 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL210239 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL61 | PODOFILOX | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL379867 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL212734 | — | IC50 | = | 2200.0 | nM | 5.66 |