Assay Detail
Functional
CHEMBL866629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cell line
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.23 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379614 | — | — | 1 | 6.70 |
| CHEMBL210880 | — | — | 1 | 6.16 |
| CHEMBL212693 | — | — | 1 | 6.00 |
| CHEMBL128748 | DIMETHYLCURCUMIN | 2.0 | 1 | 5.96 |
| CHEMBL210608 | — | — | 1 | 5.92 |
| CHEMBL210241 | — | — | 1 | 5.89 |
| CHEMBL379426 | — | — | 1 | 5.62 |
| CHEMBL128729 | — | — | 1 | 5.62 |
| CHEMBL212610 | — | — | 1 | 5.51 |
| CHEMBL208587 | — | — | 1 | 5.46 |
| CHEMBL423698 | — | — | 1 | 5.42 |
| CHEMBL208656 | — | — | 1 | 5.34 |
| CHEMBL211337 | — | — | 1 | 5.29 |
| CHEMBL210959 | — | — | 1 | 5.26 |
| CHEMBL209199 | — | — | 1 | 5.22 |
| CHEMBL377858 | — | — | 1 | 5.21 |
| CHEMBL211758 | — | — | 1 | 5.20 |
| CHEMBL211812 | — | — | 1 | 5.20 |
| CHEMBL208935 | — | — | 1 | 5.19 |
| CHEMBL209677 | — | — | 1 | 5.16 |
| CHEMBL211495 | — | — | 1 | 5.11 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.11 |
| CHEMBL378435 | — | — | 1 | 5.11 |
| CHEMBL211958 | — | — | 1 | 5.10 |
| CHEMBL211348 | — | — | 1 | 5.09 |
| CHEMBL268937 | — | — | 1 | 5.09 |
| CHEMBL211338 | — | — | 1 | 5.07 |
| CHEMBL210395 | — | — | 1 | 5.05 |
| CHEMBL210042 | — | — | 1 | 5.04 |
| CHEMBL212475 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379614 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL210880 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL212693 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL128748 | DIMETHYLCURCUMIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL210608 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL210241 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL379426 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL128729 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL212610 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL208587 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL423698 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL208656 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL211337 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL210959 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL209199 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL377858 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL211758 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL211812 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL208935 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL209677 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL211495 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL140 | CURCUMIN | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL378435 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL211958 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL268937 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL211348 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL211338 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL210395 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL210042 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL212475 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL211236 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL427220 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL378846 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL263463 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL209726 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL209219 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL211496 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL378932 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL426862 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL384447 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL443307 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL211533 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL379951 | — | IC50 | - | — | - | |
| CHEMBL209743 | — | IC50 | > | 19800.0 | nM | - |
| CHEMBL209001 | — | IC50 | = | 4.8 | ug | - |
| CHEMBL208706 | — | IC50 | > | 27400.0 | nM | - |
| CHEMBL377870 | — | IC50 | > | 10000.0 | nM | - |