Assay Detail
Functional
CHEMBL866639
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Repolarization of beta-TC3 cells
22
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Beta-TC3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.14 | 7.70 |
| Emax | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134168 | — | — | 1 | 7.70 |
| CHEMBL212041 | — | — | 1 | 6.89 |
| CHEMBL210749 | — | — | 1 | 6.85 |
| CHEMBL383992 | — | — | 1 | 6.80 |
| CHEMBL212479 | — | — | 1 | 6.40 |
| CHEMBL379292 | — | — | 1 | 6.32 |
| CHEMBL210864 | — | — | 1 | 6.30 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.30 |
| CHEMBL208928 | — | — | 1 | 6.30 |
| CHEMBL209313 | — | — | 1 | 5.70 |
| CHEMBL445321 | — | — | 1 | 5.51 |
| CHEMBL210948 | — | — | 2 | 5.46 |
| CHEMBL378871 | — | — | 2 | 5.44 |
| CHEMBL210673 | — | — | 1 | 5.30 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.86 |
| CHEMBL438967 | — | — | 1 | - |
| CHEMBL210419 | — | — | 1 | - |
| CHEMBL210210 | — | — | 1 | - |
| CHEMBL212476 | — | — | 1 | - |
| CHEMBL441686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134168 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL212041 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL210749 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL383992 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL212479 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL379292 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL208928 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL210864 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL209313 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL445321 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL210948 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL378871 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL210673 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL438967 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL210419 | — | EC50 | - | — | - | |
| CHEMBL378871 | — | Emax | < | 60.0 | % | - |
| CHEMBL210948 | — | Emax | < | 60.0 | % | - |
| CHEMBL210210 | — | EC50 | - | — | - | |
| CHEMBL212476 | — | EC50 | - | — | - | |
| CHEMBL441686 | — | EC50 | - | — | - |