Assay Detail
Functional
CHEMBL866645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against F5.12-Akt cells by MTT assay in presence of 5 uM ATP
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | F5.12 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.76 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377603 | — | — | 1 | 6.70 |
| CHEMBL210209 | — | — | 1 | 6.60 |
| CHEMBL211281 | — | — | 1 | 6.41 |
| CHEMBL210954 | — | — | 1 | 6.40 |
| CHEMBL426140 | — | — | 1 | 6.40 |
| CHEMBL383264 | — | — | 1 | 6.38 |
| CHEMBL210940 | — | — | 1 | 6.35 |
| CHEMBL209281 | — | — | 1 | 6.21 |
| CHEMBL209826 | — | — | 1 | 6.08 |
| CHEMBL212566 | — | — | 1 | 6.03 |
| CHEMBL211065 | — | — | 1 | 6.01 |
| CHEMBL379963 | — | — | 1 | 5.92 |
| CHEMBL211774 | — | — | 1 | 5.89 |
| CHEMBL209503 | — | — | 1 | 5.89 |
| CHEMBL208761 | — | — | 1 | 5.82 |
| CHEMBL211932 | — | — | 1 | 5.73 |
| CHEMBL378827 | — | — | 1 | 5.70 |
| CHEMBL210034 | — | — | 1 | 5.66 |
| CHEMBL211011 | — | — | 1 | 5.57 |
| CHEMBL380004 | — | — | 1 | 5.50 |
| CHEMBL211690 | — | — | 1 | 5.32 |
| CHEMBL207217 | — | — | 1 | 5.06 |
| CHEMBL212067 | — | — | 1 | 4.93 |
| CHEMBL376959 | — | — | 1 | 4.52 |
| CHEMBL211434 | — | — | 1 | 4.40 |
| CHEMBL209231 | — | — | 1 | 4.40 |
| CHEMBL438439 | — | — | 1 | - |
| CHEMBL377687 | — | — | 1 | - |
| CHEMBL210237 | — | — | 1 | - |
| CHEMBL379342 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377603 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL210209 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL211281 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL210954 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL426140 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL383264 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL210940 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL209281 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL209826 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL212566 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL211065 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL379963 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL211774 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL209503 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL208761 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL211932 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL378827 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL210034 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL211011 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL380004 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL211690 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL207217 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL212067 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL376959 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL211434 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL209231 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL438431 | — | IC50 | - | — | - | |
| CHEMBL207139 | — | IC50 | - | — | - | |
| CHEMBL211224 | — | IC50 | - | — | - | |
| CHEMBL209005 | — | IC50 | - | — | - | |
| CHEMBL379576 | — | IC50 | - | — | - | |
| CHEMBL378977 | — | IC50 | - | — | - | |
| CHEMBL263512 | — | IC50 | - | — | - | |
| CHEMBL379342 | — | IC50 | - | — | - | |
| CHEMBL210237 | — | IC50 | - | — | - | |
| CHEMBL377687 | — | IC50 | - | — | - | |
| CHEMBL438439 | — | IC50 | - | — | - |