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Assay Detail

CHEMBL866684

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymerase
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus subtype 1b
Confidence 8 — Homologous single protein target
Curated By Expert

Target

RNA-directed RNA polymerase (CHEMBL4296320) ↗
Type SINGLE PROTEIN
Organism Hepacivirus hominis

Publication

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.
Hirashima S, Suzuki T, Ishida T, Noji S, Yata S, Ando I, Komatsu M, Ikeda S, Hashimoto H.
J Med Chem (2006) 49 : 4721 -4736
PubMed 16854079 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 7.29 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL378026 — — 1 7.92
CHEMBL378053 — — 1 7.92
CHEMBL438430 — — 1 7.89
CHEMBL375133 — — 1 7.89
CHEMBL213695 — — 1 7.85
CHEMBL368589 — — 1 7.85
CHEMBL379435 — — 1 7.85
CHEMBL376688 — — 1 7.82
CHEMBL378470 — — 1 7.80
CHEMBL374567 — — 1 7.80
CHEMBL211849 — — 1 7.75
CHEMBL411712 — — 1 7.75
CHEMBL211639 — — 1 7.75
CHEMBL377813 — — 1 7.72
CHEMBL214365 — — 1 7.68
CHEMBL380002 — — 1 7.68
CHEMBL213807 — — 1 7.68
CHEMBL208585 — — 1 7.66
CHEMBL379931 — — 1 7.66
CHEMBL378469 — — 1 7.64
CHEMBL376462 — — 1 7.62
CHEMBL209853 — — 1 7.54
CHEMBL212363 — — 1 7.50
CHEMBL378218 — — 1 7.50
CHEMBL24396 — — 1 7.43
CHEMBL373786 — — 1 7.39
CHEMBL209425 — — 1 7.30
CHEMBL211507 — — 1 7.30
CHEMBL212582 — — 1 7.28
CHEMBL209681 — — 1 7.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL378026 — IC50 = 12.0 nM 7.92
CHEMBL378053 — IC50 = 12.0 nM 7.92
CHEMBL375133 — IC50 = 13.0 nM 7.89
CHEMBL438430 — IC50 = 13.0 nM 7.89
CHEMBL213695 — IC50 = 14.0 nM 7.85
CHEMBL368589 — IC50 = 14.0 nM 7.85
CHEMBL379435 — IC50 = 14.0 nM 7.85
CHEMBL376688 — IC50 = 15.0 nM 7.82
CHEMBL378470 — IC50 = 16.0 nM 7.80
CHEMBL374567 — IC50 = 16.0 nM 7.80
CHEMBL211849 — IC50 = 18.0 nM 7.75
CHEMBL411712 — IC50 = 18.0 nM 7.75
CHEMBL211639 — IC50 = 18.0 nM 7.75
CHEMBL377813 — IC50 = 19.0 nM 7.72
CHEMBL213807 — IC50 = 21.0 nM 7.68
CHEMBL214365 — IC50 = 21.0 nM 7.68
CHEMBL380002 — IC50 = 21.0 nM 7.68
CHEMBL208585 — IC50 = 22.0 nM 7.66
CHEMBL379931 — IC50 = 22.0 nM 7.66
CHEMBL378469 — IC50 = 23.0 nM 7.64
CHEMBL376462 — IC50 = 24.0 nM 7.62
CHEMBL209853 — IC50 = 29.0 nM 7.54
CHEMBL212363 — IC50 = 32.0 nM 7.50
CHEMBL378218 — IC50 = 32.0 nM 7.50
CHEMBL24396 — IC50 = 37.0 nM 7.43
CHEMBL373786 — IC50 = 41.0 nM 7.39
CHEMBL209425 — IC50 = 50.0 nM 7.30
CHEMBL211507 — IC50 = 50.0 nM 7.30
CHEMBL212582 — IC50 = 53.0 nM 7.28
CHEMBL209681 — IC50 = 55.0 nM 7.26
CHEMBL373930 — IC50 = 58.0 nM 7.24
CHEMBL211213 — IC50 = 63.0 nM 7.20
CHEMBL377889 — IC50 = 69.0 nM 7.16
CHEMBL209396 — IC50 = 90.0 nM 7.05
CHEMBL378546 — IC50 = 98.0 nM 7.01
CHEMBL387301 — IC50 = 100.0 nM 7.00
CHEMBL211649 — IC50 = 100.0 nM 7.00
CHEMBL378524 — IC50 = 150.0 nM 6.82
CHEMBL210297 — IC50 = 170.0 nM 6.77
CHEMBL212583 — IC50 = 170.0 nM 6.77
CHEMBL209921 — IC50 = 188.0 nM 6.73
CHEMBL212677 — IC50 = 200.0 nM 6.70
CHEMBL209282 — IC50 = 290.0 nM 6.54
CHEMBL379796 — IC50 = 350.0 nM 6.46
CHEMBL377907 — IC50 = 380.0 nM 6.42
CHEMBL378284 — IC50 = 480.0 nM 6.32
CHEMBL208843 — IC50 = 580.0 nM 6.24
CHEMBL384679 — IC50 = 930.0 nM 6.03
CHEMBL212226 — IC50 = 1100.0 nM 5.96