Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL866685

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of HCV subgenomic RNA replication in Huh5-2 cells after 48 hrs by replicon assay
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-5-2
Confidence 1 — Organism
Curated By Intermediate

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.
Hirashima S, Suzuki T, Ishida T, Noji S, Yata S, Ando I, Komatsu M, Ikeda S, Hashimoto H.
J Med Chem (2006) 49 : 4721 -4736
PubMed 16854079 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 44 6.06 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL377813 — — 1 6.85
CHEMBL374567 — — 1 6.82
CHEMBL380002 — — 1 6.80
CHEMBL378026 — — 1 6.80
CHEMBL375133 — — 1 6.70
CHEMBL411712 — — 1 6.57
CHEMBL379435 — — 1 6.55
CHEMBL210297 — — 1 6.50
CHEMBL211849 — — 1 6.47
CHEMBL212363 — — 1 6.46
CHEMBL378053 — — 1 6.44
CHEMBL376688 — — 1 6.43
CHEMBL368589 — — 1 6.42
CHEMBL214365 — — 1 6.42
CHEMBL213695 — — 1 6.34
CHEMBL211639 — — 1 6.28
CHEMBL208585 — — 1 6.21
CHEMBL378469 — — 1 6.18
CHEMBL438430 — — 1 6.10
CHEMBL373786 — — 1 6.09
CHEMBL378218 — — 1 6.08
CHEMBL213807 — — 1 6.03
CHEMBL209853 — — 1 5.96
CHEMBL212582 — — 1 5.92
CHEMBL379931 — — 1 5.89
CHEMBL209681 — — 1 5.89
CHEMBL209921 — — 1 5.82
CHEMBL378470 — — 1 5.82
CHEMBL24396 — — 1 5.80
CHEMBL211649 — — 1 5.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL377813 — EC50 = 140.0 nM 6.85
CHEMBL374567 — EC50 = 150.0 nM 6.82
CHEMBL378026 — EC50 = 160.0 nM 6.80
CHEMBL380002 — EC50 = 160.0 nM 6.80
CHEMBL375133 — EC50 = 200.0 nM 6.70
CHEMBL411712 — EC50 = 270.0 nM 6.57
CHEMBL379435 — EC50 = 280.0 nM 6.55
CHEMBL210297 — EC50 = 320.0 nM 6.50
CHEMBL211849 — EC50 = 340.0 nM 6.47
CHEMBL212363 — EC50 = 350.0 nM 6.46
CHEMBL378053 — EC50 = 360.0 nM 6.44
CHEMBL376688 — EC50 = 370.0 nM 6.43
CHEMBL368589 — EC50 = 380.0 nM 6.42
CHEMBL214365 — EC50 = 380.0 nM 6.42
CHEMBL213695 — EC50 = 460.0 nM 6.34
CHEMBL211639 — EC50 = 530.0 nM 6.28
CHEMBL208585 — EC50 = 620.0 nM 6.21
CHEMBL378469 — EC50 = 660.0 nM 6.18
CHEMBL438430 — EC50 = 790.0 nM 6.10
CHEMBL373786 — EC50 = 820.0 nM 6.09
CHEMBL378218 — EC50 = 840.0 nM 6.08
CHEMBL213807 — EC50 = 940.0 nM 6.03
CHEMBL209853 — EC50 = 1100.0 nM 5.96
CHEMBL212582 — EC50 = 1200.0 nM 5.92
CHEMBL379931 — EC50 = 1300.0 nM 5.89
CHEMBL209681 — EC50 = 1300.0 nM 5.89
CHEMBL209921 — EC50 = 1500.0 nM 5.82
CHEMBL378470 — EC50 = 1500.0 nM 5.82
CHEMBL24396 — EC50 = 1600.0 nM 5.80
CHEMBL211649 — EC50 = 2400.0 nM 5.62
CHEMBL377889 — EC50 = 2500.0 nM 5.60
CHEMBL211213 — EC50 = 2600.0 nM 5.58
CHEMBL209282 — EC50 = 2600.0 nM 5.58
CHEMBL209396 — EC50 = 2900.0 nM 5.54
CHEMBL211507 — EC50 = 3000.0 nM 5.52
CHEMBL209425 — EC50 = 3000.0 nM 5.52
CHEMBL378546 — EC50 = 3400.0 nM 5.47
CHEMBL212677 — EC50 = 3700.0 nM 5.43
CHEMBL378524 — EC50 = 3900.0 nM 5.41
CHEMBL212583 — EC50 = 6300.0 nM 5.20
CHEMBL378284 — EC50 = 6500.0 nM 5.19
CHEMBL373930 — EC50 > 10000.0 nM -
CHEMBL376462 — EC50 > 10000.0 nM -
CHEMBL208843 — EC50 > 10000.0 nM -