Assay Detail
Functional
CHEMBL866794
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.19 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210749 | — | — | 1 | 6.80 |
| CHEMBL212041 | — | — | 1 | 6.75 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.72 |
| CHEMBL212479 | — | — | 1 | 6.28 |
| CHEMBL379292 | — | — | 1 | 6.09 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210749 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL212041 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL212479 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL379292 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 33000.0 | nM | 4.48 |