Assay Detail
Functional
CHEMBL867016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARdelta transfected in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.57 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202609 | — | — | 1 | 7.92 |
| CHEMBL202118 | — | — | 1 | 7.40 |
| CHEMBL118939 | — | — | 1 | 6.89 |
| CHEMBL201803 | — | — | 1 | 6.30 |
| CHEMBL120009 | — | — | 1 | 6.16 |
| CHEMBL382655 | — | — | 1 | 6.16 |
| CHEMBL201832 | — | — | 1 | 6.00 |
| CHEMBL426483 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202609 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL202118 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL118939 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL201803 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL120009 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL382655 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL201832 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL426483 | — | EC50 | = | 2000.0 | nM | 5.70 |