Assay Detail
Binding
CHEMBL867027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against GABAT
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
4-aminobutyrate aminotransferase, mitochondrial (CHEMBL2044) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.89 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378577 | — | — | 1 | 5.26 |
| CHEMBL202519 | — | — | 1 | 4.81 |
| CHEMBL378361 | — | — | 1 | 4.81 |
| CHEMBL14193 | 4-HYDROXYBENZALDEHYDE | — | 1 | 4.78 |
| CHEMBL13883 | VANILLIN | -1.0 | 1 | 4.77 |
| CHEMBL202132 | PARAHYDROXYBENZYL ALCOHOL | — | 1 | - |
| CHEMBL312311 | PAROXYPROPIONE | 2.0 | 1 | - |
| CHEMBL201083 | 4-HYDROXYACETOPHENONE | — | 1 | - |
| CHEMBL542 | AMINOBENZOIC ACID | -1.0 | 1 | - |
| CHEMBL441343 | PARABEN | — | 1 | - |
| CHEMBL274739 | GASTRODIN | — | 1 | - |
| CHEMBL201358 | HELICIDE | — | 1 | - |
| CHEMBL161598 | ANISALDEHYDE | — | 1 | - |
| CHEMBL202440 | — | — | 1 | - |
| CHEMBL202611 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378577 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL202519 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL378361 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL14193 | 4-HYDROXYBENZALDEHYDE | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL13883 | VANILLIN | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL202132 | PARAHYDROXYBENZYL ALCOHOL | IC50 | > | 1000000.0 | nM | - |
| CHEMBL312311 | PAROXYPROPIONE | IC50 | = | 176000.0 | nM | - |
| CHEMBL201083 | 4-HYDROXYACETOPHENONE | IC50 | = | 188000.0 | nM | - |
| CHEMBL542 | AMINOBENZOIC ACID | IC50 | > | 1000000.0 | nM | - |
| CHEMBL441343 | PARABEN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL274739 | GASTRODIN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL201358 | HELICIDE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL161598 | ANISALDEHYDE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL202440 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL202611 | — | IC50 | > | 1000000.0 | nM | - |