Assay Detail
Binding
CHEMBL867029
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Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay
113
Total Activities
113
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 113 | 6.66 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372357 | — | — | 1 | 8.00 |
| CHEMBL202319 | — | — | 1 | 7.89 |
| CHEMBL202317 | — | — | 1 | 7.70 |
| CHEMBL425221 | — | — | 1 | 7.68 |
| CHEMBL202405 | — | — | 1 | 7.68 |
| CHEMBL379033 | — | — | 1 | 7.64 |
| CHEMBL380686 | — | — | 1 | 7.62 |
| CHEMBL370203 | — | — | 1 | 7.57 |
| CHEMBL203426 | — | — | 1 | 7.50 |
| CHEMBL176058 | — | — | 1 | 7.50 |
| CHEMBL201558 | — | — | 1 | 7.48 |
| CHEMBL201690 | — | — | 1 | 7.47 |
| CHEMBL201332 | — | — | 1 | 7.44 |
| CHEMBL203254 | — | — | 1 | 7.39 |
| CHEMBL201406 | — | — | 1 | 7.37 |
| CHEMBL202165 | — | — | 1 | 7.36 |
| CHEMBL201769 | — | — | 1 | 7.33 |
| CHEMBL201600 | — | — | 1 | 7.33 |
| CHEMBL202595 | — | — | 1 | 7.32 |
| CHEMBL201385 | — | — | 1 | 7.31 |
| CHEMBL201456 | — | — | 1 | 7.28 |
| CHEMBL426302 | — | — | 1 | 7.21 |
| CHEMBL201337 | — | — | 1 | 7.21 |
| CHEMBL377275 | — | — | 1 | 7.19 |
| CHEMBL371635 | — | — | 1 | 7.11 |
| CHEMBL381010 | — | — | 1 | 7.10 |
| CHEMBL201063 | — | — | 1 | 7.09 |
| CHEMBL201088 | — | — | 1 | 7.09 |
| CHEMBL201436 | — | — | 1 | 7.09 |
| CHEMBL383170 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372357 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL202319 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL202317 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL202405 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL425221 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL379033 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL380686 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL370203 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL176058 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL203426 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL201558 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL201690 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL201332 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL203254 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL201406 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL202165 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL201769 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL201600 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL202595 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL201385 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL201456 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL201337 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL426302 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL377275 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL371635 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL381010 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL201088 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL201063 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL201436 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL383170 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL201814 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL201660 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL381529 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL382628 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL202164 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL202310 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL202271 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL380442 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL201604 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL201341 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL201567 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL203312 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL180974 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL202062 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL201119 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL201603 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL381218 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL201815 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL201873 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL202514 | — | IC50 | = | 316.0 | nM | 6.50 |