Assay Detail
Binding
CHEMBL867119
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Binding affinity to human thyroid hormone receptor beta 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thyroid receptor ligands. Part 4: 4'-amido bioisosteric ligands selective for the thyroid hormone receptor beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.58 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381937 | — | — | 1 | 8.37 |
| CHEMBL204609 | — | — | 1 | 7.80 |
| CHEMBL202940 | — | — | 1 | 7.75 |
| CHEMBL202336 | — | — | 1 | 7.35 |
| CHEMBL205171 | — | — | 1 | 7.33 |
| CHEMBL202521 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381937 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL204609 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL202940 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL202336 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL205171 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL202521 | — | IC50 | = | 140.0 | nM | 6.85 |