Assay Detail
Binding
CHEMBL867220
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Inhibitory activity against VEGFR-1 using 2 uM ATP by HTRF assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-((1H-Azol-1-yl)methyl)-N-arylbenzamides: novel dual inhibitors of VEGFR-1/2 kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.38 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.00 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 6.85 |
| CHEMBL382855 | — | — | 1 | 6.85 |
| CHEMBL202011 | — | — | 1 | 6.80 |
| CHEMBL153843 | — | — | 1 | 6.77 |
| CHEMBL425587 | — | — | 1 | 6.75 |
| CHEMBL203003 | — | — | 1 | 6.66 |
| CHEMBL204548 | — | — | 1 | 6.66 |
| CHEMBL205984 | — | — | 1 | 6.58 |
| CHEMBL206279 | — | — | 1 | 6.52 |
| CHEMBL206348 | — | — | 1 | 6.47 |
| CHEMBL377081 | — | — | 1 | 6.47 |
| CHEMBL203167 | — | — | 1 | 6.44 |
| CHEMBL437889 | — | — | 1 | 6.39 |
| CHEMBL204099 | — | — | 1 | 6.36 |
| CHEMBL206403 | — | — | 1 | 6.31 |
| CHEMBL203243 | — | — | 1 | 6.27 |
| CHEMBL202643 | — | — | 1 | 6.24 |
| CHEMBL380932 | — | — | 1 | 6.21 |
| CHEMBL206185 | — | — | 1 | 6.16 |
| CHEMBL202805 | — | — | 1 | 6.13 |
| CHEMBL203965 | — | — | 1 | 6.12 |
| CHEMBL382584 | — | — | 1 | 6.11 |
| CHEMBL203063 | — | — | 1 | 6.02 |
| CHEMBL205413 | — | — | 1 | 5.94 |
| CHEMBL382478 | — | — | 1 | 5.94 |
| CHEMBL205610 | — | — | 1 | 5.90 |
| CHEMBL380503 | — | — | 1 | 5.60 |
| CHEMBL379888 | — | — | 1 | - |
| CHEMBL382256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24828 | VANDETANIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL101253 | VATALANIB | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL382855 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL202011 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL153843 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL425587 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL203003 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL204548 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL205984 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL206279 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL206348 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL377081 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL203167 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL437889 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL204099 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL206403 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL203243 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL202643 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL380932 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL206185 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL202805 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL203965 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL382584 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL203063 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL205413 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL382478 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL205610 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL380503 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL203429 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL377952 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL205401 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206215 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL202682 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL205876 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206567 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL381786 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL203110 | — | IC50 | - | — | - | |
| CHEMBL382596 | — | IC50 | - | — | - | |
| CHEMBL205138 | — | IC50 | - | — | - | |
| CHEMBL382256 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL379888 | — | IC50 | > | 10000.0 | nM | - |