Assay Detail
Functional
CHEMBL867222
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Inhibition of TLR2 agonist Pam3Cys-Ser-(Lys)4-OH-mediated IL8 secretion in THP1 cells
8
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Lipolanthionine peptides act as inhibitors of TLR2-mediated IL-8 secretion. Synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 6 | - | - |
| IC50 | 2 | 5.30 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111077 | MYRISTIC ACID | -1.0 | 2 | 5.30 |
| CHEMBL82293 | PALMITIC ACID | -1.0 | 2 | 5.30 |
| CHEMBL265816 | — | — | 1 | - |
| CHEMBL414583 | — | — | 1 | - |
| CHEMBL387425 | — | — | 1 | - |
| CHEMBL374491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111077 | MYRISTIC ACID | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL82293 | PALMITIC ACID | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL265816 | — | Activity | - | — | - | |
| CHEMBL414583 | — | Activity | - | — | - | |
| CHEMBL387425 | — | Activity | - | — | - | |
| CHEMBL374491 | — | Activity | - | — | - | |
| CHEMBL111077 | MYRISTIC ACID | Activity | = | 86.0 | % | - |
| CHEMBL82293 | PALMITIC ACID | Activity | = | 68.0 | % | - |