Assay Detail
Functional
CHEMBL867264
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Antiproliferative activity against human K562 cell line
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.96 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212515 | — | — | 1 | 8.55 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.44 |
| CHEMBL379867 | — | — | 1 | 8.43 |
| CHEMBL210239 | — | — | 1 | 8.35 |
| CHEMBL380060 | — | — | 1 | 8.33 |
| CHEMBL212734 | — | — | 1 | 8.19 |
| CHEMBL379165 | — | — | 1 | 8.11 |
| CHEMBL209011 | — | — | 1 | 8.00 |
| CHEMBL378632 | — | — | 1 | 7.83 |
| CHEMBL379863 | — | — | 1 | 7.15 |
| CHEMBL212682 | — | — | 1 | 7.07 |
| CHEMBL208955 | — | — | 1 | 6.66 |
| CHEMBL212462 | — | — | 1 | 6.47 |
| CHEMBL211149 | — | — | 1 | 6.44 |
| CHEMBL209367 | — | — | 1 | 6.10 |
| CHEMBL210549 | — | — | 1 | 5.96 |
| CHEMBL211122 | — | — | 1 | 5.90 |
| CHEMBL379631 | — | — | 1 | 5.83 |
| CHEMBL378348 | — | — | 1 | 5.78 |
| CHEMBL212683 | — | — | 1 | 5.33 |
| CHEMBL211863 | — | — | 1 | 5.07 |
| CHEMBL212219 | — | — | 1 | 5.05 |
| CHEMBL209318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212515 | — | IC50 | = | 2.82 | nM | 8.55 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL379867 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL210239 | — | IC50 | = | 4.47 | nM | 8.35 |
| CHEMBL380060 | — | IC50 | = | 4.72 | nM | 8.33 |
| CHEMBL212734 | — | IC50 | = | 6.42 | nM | 8.19 |
| CHEMBL379165 | — | IC50 | = | 7.75 | nM | 8.11 |
| CHEMBL209011 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL378632 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL379863 | — | IC50 | = | 70.3 | nM | 7.15 |
| CHEMBL212682 | — | IC50 | = | 85.5 | nM | 7.07 |
| CHEMBL208955 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL212462 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL211149 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL209367 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL210549 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL211122 | — | IC50 | = | 1267.0 | nM | 5.90 |
| CHEMBL379631 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL378348 | — | IC50 | = | 1677.0 | nM | 5.78 |
| CHEMBL212683 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL211863 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL212219 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL209318 | — | IC50 | > | 10000.0 | nM | - |