Assay Detail
Binding
CHEMBL867291
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Displacement of [3H]WIN-35428 from human DAT
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.78 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214209 | — | — | 1 | 8.42 |
| CHEMBL1790051 | — | — | 1 | 7.64 |
| CHEMBL385359 | — | — | 1 | 7.16 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
| CHEMBL211372 | — | — | 1 | 6.89 |
| CHEMBL380056 | — | — | 1 | 6.82 |
| CHEMBL379333 | — | — | 1 | 6.80 |
| CHEMBL378243 | — | — | 1 | 6.77 |
| CHEMBL378483 | — | — | 1 | 6.54 |
| CHEMBL379755 | — | — | 1 | 6.41 |
| CHEMBL386978 | — | — | 1 | 6.39 |
| CHEMBL379181 | — | — | 1 | 6.31 |
| CHEMBL211494 | — | — | 1 | 6.05 |
| CHEMBL212328 | — | — | 1 | 5.72 |
| CHEMBL211396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214209 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1790051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL385359 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL211372 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL380056 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL379333 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL378243 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL378483 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL379755 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL386978 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL379181 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL211494 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL212328 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL211396 | — | IC50 | > | 2000.0 | nM | - |