Assay Detail
Functional
CHEMBL867324
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Cytotoxicity against MiaPaCa2 cells by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.40 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210209 | — | — | 1 | 7.07 |
| CHEMBL377603 | — | — | 1 | 6.85 |
| CHEMBL383264 | — | — | 1 | 6.23 |
| CHEMBL210954 | — | — | 1 | 6.06 |
| CHEMBL212566 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210209 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL377603 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL383264 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL210954 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL212566 | — | IC50 | = | 1710.0 | nM | 5.77 |