Assay Detail
Binding
CHEMBL867337
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Inhibition of MMP13
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of butynyloxyphenyl beta-sulfone piperidine hydroxamates as TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211770 | — | — | 1 | 8.00 |
| CHEMBL377272 | — | — | 1 | 7.89 |
| CHEMBL211726 | — | — | 1 | 7.85 |
| CHEMBL377317 | — | — | 1 | 7.68 |
| CHEMBL211487 | — | — | 1 | 7.62 |
| CHEMBL212411 | — | — | 1 | 7.41 |
| CHEMBL211274 | — | — | 1 | 7.27 |
| CHEMBL212481 | — | — | 1 | 7.16 |
| CHEMBL208841 | — | — | 1 | 7.16 |
| CHEMBL379287 | — | — | 1 | 7.13 |
| CHEMBL377862 | — | — | 1 | 7.10 |
| CHEMBL387079 | — | — | 1 | 6.94 |
| CHEMBL380049 | — | — | 1 | 6.81 |
| CHEMBL425783 | — | — | 1 | 6.75 |
| CHEMBL209970 | — | — | 1 | 6.64 |
| CHEMBL209490 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211770 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL377272 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL211726 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL377317 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL211487 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL212411 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL211274 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL212481 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL208841 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL379287 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL377862 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL387079 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL380049 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL425783 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL209970 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL209490 | — | IC50 | = | 327.0 | nM | 6.49 |