Assay Detail
Binding
CHEMBL867338
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Inhibition of MMP14
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of butynyloxyphenyl beta-sulfone piperidine hydroxamates as TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.07 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210133 | — | — | 1 | 7.92 |
| CHEMBL212411 | — | — | 1 | 7.01 |
| CHEMBL211770 | — | — | 1 | 6.59 |
| CHEMBL212481 | — | — | 1 | 6.31 |
| CHEMBL211726 | — | — | 1 | 6.31 |
| CHEMBL377317 | — | — | 1 | 6.26 |
| CHEMBL211487 | — | — | 1 | 6.14 |
| CHEMBL387079 | — | — | 1 | 6.11 |
| CHEMBL377272 | — | — | 1 | 6.05 |
| CHEMBL211274 | — | — | 1 | 6.05 |
| CHEMBL380049 | — | — | 1 | 6.02 |
| CHEMBL379763 | — | — | 1 | 5.86 |
| CHEMBL377862 | — | — | 1 | 5.82 |
| CHEMBL379287 | — | — | 1 | 5.72 |
| CHEMBL208841 | — | — | 1 | 5.68 |
| CHEMBL425783 | — | — | 1 | 5.56 |
| CHEMBL209970 | — | — | 1 | 5.33 |
| CHEMBL212205 | — | — | 1 | 5.31 |
| CHEMBL210084 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210133 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL212411 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL211770 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL212481 | — | IC50 | = | 489.0 | nM | 6.31 |
| CHEMBL211726 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL377317 | — | IC50 | = | 553.0 | nM | 6.26 |
| CHEMBL211487 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL387079 | — | IC50 | = | 784.0 | nM | 6.11 |
| CHEMBL377272 | — | IC50 | = | 891.0 | nM | 6.05 |
| CHEMBL211274 | — | IC50 | = | 889.0 | nM | 6.05 |
| CHEMBL380049 | — | IC50 | = | 963.0 | nM | 6.02 |
| CHEMBL379763 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL377862 | — | IC50 | = | 1515.0 | nM | 5.82 |
| CHEMBL379287 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL208841 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL425783 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL209970 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL212205 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL210084 | — | IC50 | = | 5910.0 | nM | 5.23 |