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Assay Detail

CHEMBL867344

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant HDAC1
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Histone deacetylase 1 (CHEMBL325)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors.
Moradei O, Leit S, Zhou N, Fréchette S, Paquin I, Raeppel S, Gaudette F, Bouchain G, Woo SH, Vaisburg A, Fournel M, Kalita A, Lu A, Trachy-Bourget MC, Yan PT, Liu J, Li Z, Rahil J, MacLeod AR, Besterman JM, Delorme D.
Bioorg Med Chem Lett (2006) 16 : 4048 -4052
PubMed 16713259 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 5.44 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL211624 1 6.22
CHEMBL425960 1 5.70
CHEMBL211625 1 5.70
CHEMBL213068 1 5.70
CHEMBL378942 1 5.70
CHEMBL214211 1 5.70
CHEMBL211926 1 5.70
CHEMBL425432 1 5.70
CHEMBL213604 1 5.52
CHEMBL379516 1 5.52
CHEMBL209850 1 5.52
CHEMBL214153 1 5.52
CHEMBL211395 1 5.52
CHEMBL375409 1 5.52
CHEMBL214271 1 5.52
CHEMBL379635 1 5.40
CHEMBL211320 1 5.40
CHEMBL209762 1 5.40
CHEMBL210122 1 5.40
CHEMBL209729 1 5.40
CHEMBL211694 1 5.40
CHEMBL384503 1 5.40
CHEMBL378696 1 5.40
CHEMBL211342 1 5.30
CHEMBL424873 1 5.30
CHEMBL376427 1 5.30
CHEMBL211942 1 5.00
CHEMBL213066 1 4.77
CHEMBL378855 1 4.77
CHEMBL213071 1 4.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL211624 IC50 = 600.0 nM 6.22
CHEMBL425960 IC50 = 2000.0 nM 5.70
CHEMBL211625 IC50 = 2000.0 nM 5.70
CHEMBL213068 IC50 = 2000.0 nM 5.70
CHEMBL378942 IC50 = 2000.0 nM 5.70
CHEMBL214211 IC50 = 2000.0 nM 5.70
CHEMBL211926 IC50 = 2000.0 nM 5.70
CHEMBL425432 IC50 = 2000.0 nM 5.70
CHEMBL213604 IC50 = 3000.0 nM 5.52
CHEMBL379516 IC50 = 3000.0 nM 5.52
CHEMBL209850 IC50 = 3000.0 nM 5.52
CHEMBL214153 IC50 = 3000.0 nM 5.52
CHEMBL211395 IC50 = 3000.0 nM 5.52
CHEMBL375409 IC50 = 3000.0 nM 5.52
CHEMBL214271 IC50 = 3000.0 nM 5.52
CHEMBL379635 IC50 = 4000.0 nM 5.40
CHEMBL211320 IC50 = 4000.0 nM 5.40
CHEMBL209762 IC50 = 4000.0 nM 5.40
CHEMBL210122 IC50 = 4000.0 nM 5.40
CHEMBL209729 IC50 = 4000.0 nM 5.40
CHEMBL211694 IC50 = 4000.0 nM 5.40
CHEMBL384503 IC50 = 4000.0 nM 5.40
CHEMBL378696 IC50 = 4000.0 nM 5.40
CHEMBL211342 IC50 = 5000.0 nM 5.30
CHEMBL424873 IC50 = 5000.0 nM 5.30
CHEMBL376427 IC50 = 5000.0 nM 5.30
CHEMBL211942 IC50 = 10000.0 nM 5.00
CHEMBL213066 IC50 = 17000.0 nM 4.77
CHEMBL378855 IC50 = 17000.0 nM 4.77
CHEMBL213071 IC50 = 22000.0 nM 4.66