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Assay Detail

CHEMBL867346

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Functional
Cytotoxicity against human HMEC cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HMEC
Confidence 1 — Organism
Curated By Expert

Target

HMEC (CHEMBL614734)
Type CELL-LINE
Organism Homo sapiens

Publication

Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors.
Moradei O, Leit S, Zhou N, Fréchette S, Paquin I, Raeppel S, Gaudette F, Bouchain G, Woo SH, Vaisburg A, Fournel M, Kalita A, Lu A, Trachy-Bourget MC, Yan PT, Liu J, Li Z, Rahil J, MacLeod AR, Besterman JM, Delorme D.
Bioorg Med Chem Lett (2006) 16 : 4048 -4052
PubMed 16713259 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.62 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL211625 1 4.82
CHEMBL378942 1 4.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL211625 IC50 = 15000.0 nM 4.82
CHEMBL378942 IC50 = 39000.0 nM 4.41