Assay Detail
Functional
CHEMBL867392
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Antiproliferative activity against human HT29 cell line by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.53 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212719 | — | — | 1 | 8.70 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 8.22 |
| CHEMBL213656 | — | — | 1 | 7.52 |
| CHEMBL379964 | — | — | 1 | 7.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.82 |
| CHEMBL151423 | — | — | 1 | 6.70 |
| CHEMBL215398 | — | — | 1 | 6.70 |
| CHEMBL212960 | — | — | 1 | 6.52 |
| CHEMBL213260 | — | — | 1 | 6.00 |
| CHEMBL213484 | — | — | 1 | 5.92 |
| CHEMBL213205 | — | — | 1 | 5.80 |
| CHEMBL212132 | — | — | 1 | 5.68 |
| CHEMBL377119 | — | — | 1 | 5.48 |
| CHEMBL213485 | — | — | 1 | 5.26 |
| CHEMBL212603 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212719 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL213656 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL379964 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL151423 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL215398 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL212960 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL213260 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL213484 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL213205 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL212132 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL377119 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL213485 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL212603 | — | IC50 | = | 6900.0 | nM | 5.16 |