Assay Detail
Functional
CHEMBL867526
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Inhibition of estrogen receptor in Ishikawa cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ishikawa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.09 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379415 | — | — | 1 | 7.92 |
| CHEMBL206680 | — | — | 1 | 7.89 |
| CHEMBL207324 | — | — | 1 | 7.77 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 7.64 |
| CHEMBL208085 | — | — | 1 | 7.36 |
| CHEMBL426322 | — | — | 1 | 7.10 |
| CHEMBL381489 | — | — | 1 | 7.00 |
| CHEMBL207362 | — | — | 1 | 6.76 |
| CHEMBL210648 | — | — | 1 | 6.75 |
| CHEMBL210699 | — | — | 1 | 6.39 |
| CHEMBL209090 | — | — | 1 | 5.42 |
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379415 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL206680 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL207324 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL208085 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL426322 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL381489 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL207362 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL210648 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL210699 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL209090 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL691 | ETHINYL ESTRADIOL | IC50 | - | — | - |